Altered glia to neuron signaling significantly impact pathological development in neurodegenerative diseases. Intercellular exosome signaling emerges as a new pathway that has been implicated in different neurodegenerative diseases. In this seminar, I will be talking about our efforts in understanding exosome-dependent neuron to glia signaling and how cell-type specific exosome signaling is differentially involved in neurodegenerative diseases.