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Reseach Happy Hour
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Please join us for a virtual Research Happy Hour at the DACCPM!

Dear Colleagues,

We are delighted to have Dr. Long-Jun Wu joining us for the next Research Happy Hour. Dr. Long-Jun Wu obtained PhD of Neurobiology from University of Science and Technology of China in 2004. He received his postdoc trainings at University of Toronto (2004-2008) and Harvard Medical School (2008-2011). Prior to UTHealth Houston, he was Professor of Neurology and Associate Director for Neuroscience PhD program at Mayo Clinic. Currently, Dr. Wu is Professor and Founding director of Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine at UTHealth Houston. He is C. Harold and Lorine G. Wallace Distinguished University Chair. Dr. Wu’s current recent research primarily focuses on the neuroimmune interaction, particularly the function of microglia, in normal and diseased brain. Dr. Wu has published more than 180 peer-reviewed articles, including those in Nature Neuroscience, Neuron, Science Translational Medicine, Nature Communications, Journal of Clinical Investigation, PNAS, etc. His work is impactful in the field with more than 17000 citations and H index of 73 (Google Scholar, 12/2024). He received NINDS Outstanding Investigator Award (R35) in 2023, and was the Teacher of the Year at Mayo Clinic Graduate School of Biomedical Science in 2020. Dr. Wu was a standing member for NIH CMBG study section and ad hoc reviewer for multiple study sections. He serves as an Associate Editor for Neuroscience, Molecular Brain, Neuroscience Bulletin and Cell & Biosciences as well as in editorial boards for a number of journals including Glia, Brain Behavior and Immunity, Molecular Pain.

All talks and discussions are now featured at our new webpage: Research Happy Hour.

Yiying Zhang, host of this RHH

Upcoming

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Monday, January 27, 2025, 11:00 AM – 12:00 PM EDT
Location: CNY Building 149, 1-1303A or click to join remotely: https://partners.zoom.us/j/9788576196?omn=86433927240

Photo of the speaker
Long-Jun Wu, Ph.D.
C. Harold and Lorine G. Wallace Distinguished University Chair, Professor and Founding Director, IMM-Center for Neuroimmunology and Glial Biology, University of Texas Health Science Center at Houston
 
Microglia Sense and Regulate Neuronal Activity in Anesthesia
 
Microglia are resident immune cells of the central nervous system (CNS) and play key roles in brain homeostasis. Using in vivo two-photon imaging in awake/anesthesia mice, we found that microglia increase their dynamic process surveillance and interact more closely with neurons through reduced norepinephrine signaling during anesthesia. We further demonstrate that microglia enhance neuronal activity by shielding GABAergic inputs after the cessation of general anesthesia. Our studies reported a previously unappreciated function of microglial in regulation of neuronal activity in anesthesia.