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Reseach Happy Hour
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Please join us for a virtual Research Happy Hour at the DACCPM!

Dear Colleagues,

We are delighted to have Dr. David Kaczka, M.D., Ph.D., speaking about a novel multi-frequency ventilation mode aiming to improve outcomes in mechanically ventilated patients and about advanced ventilation imaging using dynamic xenon-enhanced computed tomography and four-dimensional image registration.

The meeting format will be 50% time for the presentation and 50% for discussion. Questions can be asked during the presentation and will be moderated. This format has been very successful, engaging, and inspiring for the participants. It allows us to explore details and gain insights beyond traditional talks. Some of you may know this format as the style of the legendary flow-volume-underworld meetings.

All talks and discussions are now featured at our new webpage: Research Happy Hour.

Tilo Winkler, host of this RHH


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Wednesday, April 17, 2024, 5:30 PM – 6:30 PM EDT
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Photo of the speaker
David W. Kaczka, M.D., Ph.D.
Gilbert E. Kinyon Professor, Departments of Anesthesia, Biomedical Engineering, and Radiology, University of Iowa, Iowa City, Iowa
Mechanical Ventilation of the Injured Lung: A Quantitative CT Imaging Assessment
Conventional strategies for protective mechanical ventilation in injured lungs rely on positive end-expiratory pressure to limit derecruitment and low tidal volumes or driving pressures to limit overdistention. In injured lungs, it has been demonstrated that using multiple superimposed frequencies, termed “multi-frequency ventilation” (MFV), results in a more even ventilation distribution consistent with regional mechanical properties. In this presentation, Dr. Kaczka will discuss the theoretical rationale for using MFV in structurally heterogeneous acute lung injury and demonstrate the mechanisms by which MFV improves regional ventilation distribution, aeration, and lung parenchymal strain. The assessments are based on dynamic xenon-enhanced computed tomographic imaging and four-dimensional image registration. These pre-clinical studies of MFV may establish the foundation for further explorations of novel ventilation modalities in a broad range of patients with acute respiratory failure.