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Reseach Happy Hour
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Dear Colleagues,

Please join us for a virtual Research Happy Hour at the DACCPM!

We are delighted to have Dr. Keith Miller, Ph.D., speak and discuss the recent cutting-edge paper in Nature about the heterogeneity in the assembly of GABAA receptors affecting the signaling in neural circuits (Sente A, et al. Nature 2022, that he and his colleagues published.

The meeting format will be 50% time for the presentation and 50% for discussion. Questions can be asked during the presentation and will be moderated. This format has been very successful, engaging, and inspiring for the participants. It allows us to explore details and gain insights beyond traditional talks. Some of you may know this format as the style of the legendary flow-volume-underworld meetings.

Tilo Winkler, host of the RHH


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Wednesday, September 28, 2022, 5:30 PM – 6:30 PM EDT
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Photo of the speaker
Keith Miller, Ph.D.
Mallinckrodt Professor of Pharmacology in the Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA
The GABA(A) receptor family; well behaved synaptic receptors, and unruly extra-synaptic receptors
GABA(A) receptors are the site of action of general anesthetics. They have five subunits arranged symmetrically around an ion conducting channel. There are 19 subunits, so many arrangements are possible. Anesthetics bind between specific pairs of subunits, so we expect them to act differently on different members of the GABA(A)R family. Thus, establishing which arrangements exist is important.